Networks-on-Chip (NoCs) are considered a viable solution to fully exploit the computational power of multi- and many-cores, but their non negligible power consumption requires ad hoc power-performance design methodologies. In this perspective, several proposals exploited the possibility to dynamically tune voltage and frequency for the interconnect, taking steps from traditional CPU-based power management solutions. However, the impact of the actuators, i.e. the limited range of frequencies for a PLL (Phase Locked Loop) or the time to increase voltage and frequency for a Dynamic Voltage and Frequency Scaling (DVFS) modules, are often not carefully accounted for, thus overestimating the benefits. This paper presents a control-based methodology for the NoC power-performance optimization exploiting the Dynamic Frequency Scaling (DFS). Both timing and power overheads of the actuators are considered, thanks to an ad hoc simulation framework. Moreover the proposed methodology eventually allows for user and/or OS interactions to change between different high level power-performance modes, i.e. to trigger performance oriented or power saving system behaviors. Experimental validation considered a 16-core architecture comparing our proposal with different settings of threshold-based policies. We achieved a speedup up to 3 for the timing and a reduction up to 33.17% of the power ∗ time product against the best threshold-based policy. Moreover, our best control-based scheme provides an averaged power-performance product improvement of 16.50% and 34.79% against the best and the second considered threshold-based policy setting.